Endometrial Hyperplasia

Hormones that are out of balance can cause problems with the lining of the uterus.

If you have too much of the hormone estrogen compared to progesterone, the lining can start to thicken. This can affect your menstrual cycle. (A regular cycle often helps keep the lining of the uterus thin.)

Your risk for this condition may be higher if you have:

• Polycystic ovary syndrome.
• Obesity, diabetes, or late menopause.
• Never given birth to a child.
• Tamoxifen treatment for breast cancer.

If you have abnormal vaginal bleeding, your doctor may do some tests. The tests check the lining of your uterus.

You may have a transvaginal, or pelvic, ultrasound. This test uses sound waves to make a picture of the uterus. It can measure the thickness of the lining.

You will also have a biopsy. Your doctor will take a small sample of the lining of the uterus. The sample will be checked under a microscope.

The doctor will look for certain changes in the cells that could lead to cancer. If changes are found, this is called endometrial hyperplasia with atypia. Or it may be called atypical endometrial hyperplasia.

Treatment may include:

• Watching for changes in the lining of the uterus over time.
• Taking the hormone progestin.
• Having surgery to remove the uterus (hysterectomy). In some cases, the ovaries and fallopian tubes may also be removed.

Your treatment will depend on whether the cells that line the uterus have changes that could lead to cancer. It also depends on whether you want to have children in the future.