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A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women With Stage 0, I, or II Breast Cancer

Primary aim To determine whether partial breast irradiation (PBI) limited to the region of the tumor bed following lumpectomy provides equivalent local tumor control in the breast compared to conventional whole breast irradiation (WBI) in the local management of early stage breast cancer. Secondary aims To compare overall survival, recurrence-free survival, and distant disease-free survival between women receiving PBI and women receiving WBI. To determine whether PBI delivered on 5 treatment days over a period of 5 to 10 days can provide a comparable cosmetic result to WBI. To determine if PBI produces less fatigue and treatment-related symptoms compared to WBI. To determine if perceived convenience of care is greater for women receiving PBI compared to women receiving WBI. To compare acute and late toxicities between the radiation therapy regimens.

Primary aim To determine whether partial breast irradiation (PBI) limited to the region of the tumor bed following lumpectomy provides equivalent local tumor control in the breast compared to conventional whole breast irradiation (WBI) in the local management of early stage breast cancer. Secondary aims To compare overall survival, recurrence-free survival, and distant disease-free survival between women receiving PBI and women receiving WBI. To determine whether PBI delivered on 5 treatment days over a period of 5 to 10 days can provide a comparable cosmetic result to WBI. To determine if PBI produces less fatigue and treatment-related symptoms compared to WBI. To determine if perceived convenience of care is greater for women receiving PBI compared to women receiving WBI. To compare acute and late toxicities between the radiation therapy regimens.