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A Randomized, Double-blind, Placebo-controlled, Multicenter, Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of CERC-002 in Adults with COVID-19 Pneumonia and Acute Lung Injury

Primary Objective: * To evaluate the effect of CERC-002 compared with placebo in addition to standard of care on prevention of ARDS in adults with COVID-19 pneumonia and acute lung injury. Secondary Objectives: * To evaluate the safety and tolerability of CERC-002 compared with placebo in addition to standard of care, in adults with COVID-19 pneumonia and acute lung injury. * To evaluate the effect of CERC-002 compared with placebo in addition to standard of care, on mortality in adults with COVID-19 pneumonia and acute lung injury. Exploratory Objectives: * To evaluate the effect of CERC-002 compared with placebo in addition to standard of care, on viral load in adults with COVID-19 pneumonia and acute lung injury. * To evaluate the PK, pharmacodynamics (PD), and immunogenicity of CERC-002 compared with placebo in addition to standard of care, in adults with COVID-19 pneumonia and acute lung injury.

Primary Objective: * To evaluate the effect of CERC-002 compared with placebo in addition to standard of care on prevention of ARDS in adults with COVID-19 pneumonia and acute lung injury. Secondary Objectives: * To evaluate the safety and tolerability of CERC-002 compared with placebo in addition to standard of care, in adults with COVID-19 pneumonia and acute lung injury. * To evaluate the effect of CERC-002 compared with placebo in addition to standard of care, on mortality in adults with COVID-19 pneumonia and acute lung injury. Exploratory Objectives: * To evaluate the effect of CERC-002 compared with placebo in addition to standard of care, on viral load in adults with COVID-19 pneumonia and acute lung injury. * To evaluate the PK, pharmacodynamics (PD), and immunogenicity of CERC-002 compared with placebo in addition to standard of care, in adults with COVID-19 pneumonia and acute lung injury.